Stem-Cell Based Therapy in the Treatment of Glioblastoma Multiforme
نویسندگان
چکیده
Glioblastoma Multiforme is a grade IV detrimental tumor occurring in nearly 13,000 Americans annually, presenting serious and often fatal toll on the individual suffering from tumor. However, resistant properties of cells which together form pose variety issues terms treatment, including violently spreading throughout central nervous system, disrupting blood-brain barrier, as well having survival rate forty-percent. There has yet to be guaranteed effective treatment for Glioblastoma, however, known stem-cell therapy utilizing neural stem recently gained interest common treatment. The various forms other than primarily based composition these been presented analyzed this paper, order present suggest most effective.
منابع مشابه
Neural Stem Cell Carriers for the Treatment of Glioblastoma Multiforme
Grade IV astrocytoma, termed glioblastoma multiforme (GBM) is death receptor (DR) expression on the surface of glioblastoma cells, one themost aggressive malignancies known to man. Despite intensive therapies, themedian survival has remained approximately 15months. One of themajor challenges to the treatment of CNSmalignancies is the blood brain barrier (BBB). The barrier is designed to be incr...
متن کاملCancer Stem Cell Hierarchy in Glioblastoma Multiforme
Glioblastoma multiforme (GBM), an aggressive tumor that typically exhibits treatment failure with high mortality rates, is associated with the presence of cancer stem cells (CSCs) within the tumor. CSCs possess the ability for perpetual self-renewal and proliferation, producing downstream progenitor cells that drive tumor growth. Studies of many cancer types have identified CSCs using specific ...
متن کاملGlioblastoma Multiforme Stem Cells
Glioblastoma multiforme (GBM) is an aggressive, malignant, and lethal brain tumor, resistant to all current forms of treatment. The rapidly emerging focus on cancer stem cells embodies a paradigm shift in our understanding of tumor pathogenesis, while the development of powerful genome-wide screening techniques has provided cause for optimism related to the development of more reliable therapie...
متن کاملDendritic Cell-Based Immunotherapy Treatment for Glioblastoma Multiforme
Glioblastoma multiforme (GBM) is the most malignant glioma and patients diagnosed with this disease had poor outcomes even treated with the combination of conventional treatment (surgery, chemotherapy, and radiation). Dendritic cells (DCs) are the most powerful antigen presenting cells and DC-based vaccination has the potential to target and eliminate GBM cells and enhance the responses of thes...
متن کاملStem cell based glioblastoma gene therapy Minireview**
There is no curative therapy for glioblastoma multiforme (GBM) thus far. Combined therapies including surgery, followed by concomitant irradiation and chemotherapy with the DNA alkylating agent temozolomide (TMZ), slightly improves patients’ survival but the prognosis remains poor. The fatal nature of glioblastoma is caused by tumor-initiating glioblastoma cells. The tumor tropic ability of adu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Student Research
سال: 2023
ISSN: ['2167-1907']
DOI: https://doi.org/10.47611/jsrhs.v12i1.4348